Worsening of Hypertension by Cyclo-oxygenase-2 Inhibitors

Worsening of Hypertension by Cyclo-oxygenase-2 Inhibitors

from Journal of Clinical Hypertension

Case 2

A 73-year-old female was seen in the Hypertension Clinic for a change in blood pressure control. Her sitting blood pressure was 176/94 mm Hg, which was similar to the readings she had been getting at home. When last seen 3 months previously, her sitting blood pressure had been 124/72 mm Hg while on Maxzide® 25 mg once daily and atenolol 50 mg, one and one-half tablet daily. Review of her health status showed that her primary care physician had recently started her on Celebrex® 200 mg/day. No other medication use or dietary indiscretions were found. The Celebrex® was discontinued and, upon her return to the clinic 4 weeks later, her sitting blood pressure was 132/80 mm Hg.

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