Tuesday, January 22, 2008

Trimethoprim-Sulfamethoxazole - A Review of Use in Children

Dosing Recommendations


TMP-SMX is currently available as Bactrim by Roche, Septra by Glaxo Wellcome, Cotrim by Lemmon, and in ware form by numerous manufacturers.
It is available as a base hit long suit (80 mg trimethoprim and 400 mg sulfamethoxazole) or reliever metier (160 mg trimethoprim and 800 mg sulfamethoxazole) dose, liquidity supporting (40mg TMP and 200mg SMX/5ml) or intravenous conceptualisation. Vino products provide approximately a 50% cost savings to the patient; however, many patients estimation that the grape-flavored form name effect tastes bettor than the ware ones.

The recommended medication regimen for children over two months of age for the direction of UTIs, Shigellosis, and acute otitis media is 8 mg/kg TMP/ 40 mg/kg SMX per day given in two divided doses every 12 period of time for ten days.
Patients with significantly impaired renal software program (creatinine way 15 to 30 ml/min) should receive one-half of the usual medicine regimen since sulfamethoxazole metabolites may accumulate.
Patients receiving hemodialysis may be given one dose after each dialysis direction.
TMP-SMX is not recommended for patients with creatinine room values less than 15 ml/min who are not receiving dialysis.

Direction of PCP requires a higher dosing regimen of 15 to 20 mg/kg TMP-SMX and 100 mg/kg SMX per day in divided doses every 6 period of time.
The intravenous dose is the same as the oral dose.
Prophylaxis dosing of PCP for children is 150 mg/m2 TMP and 750 mg/m2 SMX per day given orally in equally divided doses twice a day on tierce consecutive days per week.
This is a part of article Trimethoprim-Sulfamethoxazole - A Review of Use in Children Taken from "Bactrim Information" Information Blog

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